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Prions can be deadly

Discussion in 'Environmental Discussion' started by bwilson4web, Jul 30, 2021.

  1. bwilson4web

    bwilson4web BMW i3 and Model 3

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    Source: France issues moratorium on prion research after fatal brain disease strikes two lab workers | Science | AAAS

    Five public research institutions in France have imposed a 3-month moratorium on the study of prions—a class of misfolding, infectious proteins that cause fatal brain diseases—after a retired lab worker who handled prions in the past was diagnosed with Creutzfeldt-Jakob disease (CJD), the most common prion disease in humans. An investigation is underway to find out whether the patient, who worked at a lab run by the National Research Institute for Agriculture, Food and Environment (INRAE), contracted the disease on the job.

    If so, it would be the second such case in France in the past few years. In June 2019, an INRAE lab worker named Émilie Jaumain died at age 33, 10 years after pricking her thumb during an experiment with prion-infected mice. Her family is now suing INRAE for manslaughter and endangering life; her illness had already led to tightened safety measures at French prion labs.
    . . .    ​

    This is a good reason to throughly cook meat. The deer 'wasting' disease is another source.

    Bob Wilson
     
    #1 bwilson4web, Jul 30, 2021
  2. Trollbait

    Trollbait It's a D&D thing

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    Cooking might work for those that ask for a charred puck. The sterilization guidelines during the mad cow break out involved undiluted bleach and autoclaving times of hours. Prions have "survived" washing and disinfecting with benzene, ethanol, and formaldehyde.

    Prion - Wikipedia
    1. Immerse in 1N sodium hydroxide and place in a gravity-displacement autoclave at 121 °C for 30 minutes; clean; rinse in water; and then perform routine sterilization processes.
    2. Immerse in 1N sodium hypochlorite (20,000 parts per million available chlorine) for 1 hour; transfer instruments to water; heat in a gravity-displacement autoclave at 121 °C for 1 hour; clean; and then perform routine sterilization processes.
    3. Immerse in 1N sodium hydroxide or sodium hypochlorite (20,000 parts per million available chlorine) for 1 hour; remove and rinse in water, then transfer to an open pan and heat in a gravity-displacement (121 °C) or in a porous-load (134 °C) autoclave for 1 hour; clean; and then perform routine sterilization processes.
    Best to also keep the equipment wet after contamination, as dry films are more resistant to the process. Even then, the above still aren't 100% effective.
     
    #2 Trollbait, Jul 30, 2021
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  3. bisco

    bisco cookie crumbler

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    might still be time to correct the title. i had to look up prion, never heard of it
     
    #3 bisco, Jul 30, 2021
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  4. ETC(SS)

    ETC(SS) The OTHER One Percenter.....

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    Figures....

    I switch to a mostly plant based diet, and now all of the norms are going to start getting killed off.

    Time to start eating meat again.
     
    #4 ETC(SS), Jul 30, 2021
  5. ChapmanF

    ChapmanF Senior Member

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    Is a frion a prion domicilié en France?
     
    #5 ChapmanF, Jul 30, 2021
  6. Trollbait

    Trollbait It's a D&D thing

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    It has been some time since they were in the news.
    United Kingdom BSE outbreak - Wikipedia
    That's part of the reason for the out of country questions asked when giving blood.

    Prions are misfolded proteins. When they come in contact with the normal protein, the good one gets misfolded. Once out of shape, proteins can't do their job.
     
    #6 Trollbait, Jul 30, 2021
  7. fuzzy1

    fuzzy1 Senior Member

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    Do you remember the Mad Cow disease outbreak in the UK several decades ago, which killed a lot of people?
    I never heard of cooking meat successfully making it safe from this.
     
    #7 fuzzy1, Jul 30, 2021
  8. bisco

    bisco cookie crumbler

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    yes, i didn't realize that was the cause. our daughter was there, dipping her feet in chlorine
     
    #8 bisco, Jul 30, 2021
  9. ETC(SS)

    ETC(SS) The OTHER One Percenter.....

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    ^
    Foot fungus?

    I remember having to wait a significant amount of time after my last deployment before I was able to donate blood again (I'm O-neg) and they were always very exited about my years in Scotland back when I was knocking holes in the ocean....
     
    #9 ETC(SS), Jul 30, 2021
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  10. Mendel Leisk

    Mendel Leisk Senior Member

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    I'm sorry, but I keep reading "prisons"...

    Have to get Tideland on it. Again...
     
    #10 Mendel Leisk, Jul 30, 2021
  11. Trollbait

    Trollbait It's a D&D thing

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    Sounds like she was there for the foot-and-mouth outbreak. That's a viral infection of hoofed animals. Would not infect people, but is very easily passed around. Walk through a field with sick animals, and your shoes will carry it to other farms.
    2001 United Kingdom foot-and-mouth outbreak - Wikipedia

    edit-left out a not
     
    #11 Trollbait, Jul 30, 2021
    Last edited: Jul 30, 2021
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  12. bisco

    bisco cookie crumbler

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    that was it, thank you
     
    #12 bisco, Jul 30, 2021
  13. tochatihu

    tochatihu Senior Member

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    #13 tochatihu, Jul 30, 2021
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