2005 Prius

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Generally speaking, when you have warning lights displayed on the dash, you'll have OBD2 codes (DTCs) stored in the ECUs (computers). Best to locate a toyota hybrid compatible OBD2 scanner to retrieve the stored codes, then post them here for additional guidance.

Since you've replaced the 12v, which causes the fuel mapping to reset, it would be a good idea to clean up the MAF and throttle body now.

You might've run down the HV battery, which device did you use to "balance" the HV battery?

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check the brake switch, as well as the 12v. replacing it with a defective unit is a common problem

 

Your ICE is likely not running at all. The hybrid system will crank the engine at 1000 rpm for up to 10 seconds when it tries to start it (sounds like a start and stall). You need to go over basics before you discharge the HV battery. Does the fuel pump work and what is the fuel pressure? Clean throttle body and MAF? What does the ECM show for codes and data when you try to start? (Helps to have techstream to record and save a data movie).

When you get the P0A80, what are the HV battery block voltages?

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make sure the brake lights come on when you press the pedal, then push the power button. if they are on the switch is fine, and the problem lies elsewhere

 

internal combustion engine

 

That's... horrible. Module 21 is dead. Period. If you have more time than money, you can try cycling everything that went below 7V (second set of numbers), but I wouldn't expect too much. Generally, IF a module is fully charged and then self discharges that low- it's bad.

I might try discharging down to 6V then charge to 7500mAh (delta V disabled) at 1 amp. Then repeat but go down to 5.5V then up 8000mAh. Might recover some modules- or not.

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@Zachary Eaton

If the first voltage is day one after discharge and the second voltage is a few days after discharge, every single one of those modules that is less than 7.7 volts is not useable. I wouldn't put them in any battery, even if they looked good after trying to recover them, because there is no guarantee they won't be bad next week. You build a battery with those modules and you're going to have a P0A80 a day or two later, every time. Let the car sit a day or two and a P0A80. A good module should stay above 7.5 volts for MONTHS, not a day or two.