P0300 Misfire

I am wondering if some one may shed some light on this issue.
I am having a P0300, P0301,& P0303 code.
I have replaced spark plugs , coils .
Would a lose of worn timing chain throw those codes?
I do notice some noise in the valve train at initial start up .
it does not consume any oil.
Run perfectly fine. Averages about 45 to 48 MPG
all day long .

has a new Cat, or would the 02B1S2 be no good. As I read 0.00 Volts in my freeze data.

Before hand thank you for you help.