1. Attachments are working again! Check out this thread for more details and to report any other bugs.

SARS-CoV-2 Coronavirus (COVID-19)

Discussion in 'Environmental Discussion' started by tochatihu, Jan 26, 2020.

  1. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    107,571
    48,862
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
    you wouldn't get me into an indoor sports event, even with everyone vaccinated.

    in fact, i'm rethinking the whole flu thing in regards to public gatherings in the future. the super spreader, er, market, is a bad enough necessity.
     
  2. Salamander_King

    Salamander_King Senior Member

    Joined:
    Nov 8, 2015
    10,958
    8,836
    0
    Location:
    New England
    Vehicle:
    Other Hybrid
    Model:
    N/A
    I have not been following this thread for a while. For one thing, it seems for most general population I encounter, the pandemic seems to be already a thing of the past. I guess we are entering an Endemic era now.

    Just made a booster shot appointment. I just passed the 6 mo from the last Moderna shot. I do not qualify by age, but the CDC list of suggested people who should get a booster shot is wide enough, I think I can qualify. I will see. Moderna 1/2 shots followed by Moderna booster seems to be the most protective combination of the 9 possible boosters shot combination pairs, according to the recent NIH study published preliminary report (not peer-reviewed).

    Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report | medRxiv
     
  3. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    107,571
    48,862
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
    i have newfound faith in science with these mnra vaccines. i hope they'll be able to adjust fairly quickly to any dangerous variants, but so far, none have shown to be a major problem
     
  4. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    27,068
    15,372
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
    Good preliminary news!

    Source: Antibody-Free Rapid Detection of SARS-CoV-2 Proteins Using Corona Phase Molecular Recognition to Accelerate Development Time - PubMed

    . . . Here, we report a synthetic strategy for nanoparticle corona interfaces that enables the molecular recognition of SARS-CoV-2 proteins without any antibody and receptor design. Our nanosensor constructs consist of poly(ethylene glycol) (PEG)-phospholipid heteropolymers adsorbed onto near-infrared (nIR) fluorescent single-walled carbon nanotubes (SWCNTs) that recognize the nucleocapsid (N) and spike (S) protein of SARS-CoV-2 using unique three-dimensional (3D) nanosensor interfaces. This results in rapid and label-free nIR fluorescence detection. . . .

    This would be a game changer as the test results come back in minutes. More study needed and testing but I really like direct detection of the virus.

    Bob Wilson
     
  5. hill

    hill High Fiber Member

    Joined:
    Jun 23, 2005
    19,605
    8,036
    54
    Location:
    Montana & Nashville, TN
    Vehicle:
    2004 Prius
    Model:
    IV


    Ethylene glycol poisoning: MedlinePlus Medical Encyclopedia

    take - in really really teeny doses?

    .

     
  6. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    27,068
    15,372
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
  7. ChapmanF

    ChapmanF Senior Member

    Joined:
    Mar 30, 2008
    23,073
    14,978
    0
    Location:
    Indiana, USA
    Vehicle:
    2010 Prius
    Model:
    IV
    It would be a mistake to mix up ethylene glycol and polyethylene glycol.

    The former is car antifreeze and will kill you.

    The latter is a commonly available laxative and you may be given like a pound of it, with an instruction sheet, in advance of a colonoscopy. Unless I'm thinking of something else, there has also been some interesting work with it in minimizing nerve damage at injury sites.
     
    tochatihu likes this.
  8. Trollbait

    Trollbait It's a D&D thing

    Joined:
    Feb 7, 2006
    21,595
    11,220
    0
    Location:
    eastern Pennsylvania
    Vehicle:
    Other Non-Hybrid
    Polyethylene glycol is also a common food additive.
     
  9. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    17,038
    10,012
    90
    Location:
    Western Washington
    Vehicle:
    Other Hybrid
    Model:
    N/A
    For those somehow feeling compelled to eat these nanosensors, instead of leaving them in the laboratories as intended:

    MedlinePlus: Polyethylene Glycol 3350

    "Why is this medication prescribed?

    Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass. ..."
     
    #5051 fuzzy1, Oct 28, 2021
    Last edited: Oct 28, 2021
  10. hill

    hill High Fiber Member

    Joined:
    Jun 23, 2005
    19,605
    8,036
    54
    Location:
    Montana & Nashville, TN
    Vehicle:
    2004 Prius
    Model:
    IV
    Oops, my bad. Never has so much dialogue been stirred from a too quick a read

    .
     
  11. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    27,068
    15,372
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
    Is OK. This is PriusChat and we ran off the *ssholes years ago.

    Bob Wilson
     
  12. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    107,571
    48,862
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
  13. tochatihu

    tochatihu Senior Member

    Joined:
    Apr 10, 2004
    8,972
    3,501
    0
    Location:
    Kunming Yunnan China
    Vehicle:
    2001 Prius
    Article linked post #5044 shows just what we would expect from a virus challenged by antibodies, whether induced by infection or vaccination. New changed structures that evade antibodies do well in wetspace. I cannot pin down where the new protein sequence sections are disclosed, but one would design new antibodies that 'grab onto' those.

    The useful novelty of mRNA vaccine design is that it instructs human cells to generate those newly required antibodies, and can be developed quickly. I suppose the slow step persists, namely testing those new vaccines well enough to merit approval for use.

    Another slow step I suppose is convincing people to receive yet another vaccination. But manufacture it at scale all the same - if mortality counts rise, willingness will rise as well. I suppose. If new-antibody-making vaccines are rejected by people, you get 2021 again.
     
  14. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    27,068
    15,372
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
    From article:

    In the group that took the drug, 11% needed hospitalization or an extended ER stay, compared to 16% of those on dummy pills.

    The population study is large enough but the results are not terribly effective. I would like to see another group replicate this study. Science is full of unreproducible reports.

    Bob Wilson
     
  15. tochatihu

    tochatihu Senior Member

    Joined:
    Apr 10, 2004
    8,972
    3,501
    0
    Location:
    Kunming Yunnan China
    Vehicle:
    2001 Prius
    unreproducible -> unreproduced
     
    bwilson4web likes this.
  16. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    17,038
    10,012
    90
    Location:
    Western Washington
    Vehicle:
    Other Hybrid
    Model:
    N/A
    Also from the article:

    "The results, published Wednesday in the journal Lancet Global Health, were so strong that independent experts monitoring the study recommended stopping it early because the results were clear."

    In some other studies, this has meant quitting giving anyone the placebo, instead give everyone the drug that works so well.

    And:

    "The pill, called fluvoxamine, would cost $4 for a course of COVID-19 treatment. By comparison, antibody IV treatments cost about $2,000 and Merck's experimental antiviral pill for COVID-19 is about $700 per course. Some experts predict various treatments eventually will be used in combination to fight the coronavirus."

    "The larger project looked at eight existing drugs to see if they could work against the pandemic virus. The project is still testing a hepatitis drug, but all the others — including metformin, hydroxychloroquine and ivermectin — haven't panned out."
     
  17. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    17,038
    10,012
    90
    Location:
    Western Washington
    Vehicle:
    Other Hybrid
    Model:
    N/A
    The latest study suggests that naturally acquired immunity from having survived a covid-19 infection, is not as effective as vaccine-acquired immunity. And by quite a wide margin.


    The Hill: CDC study: Vaccination offers better protection than previous COVID-19 infection


    "A new study from the Centers for Disease Control and Prevention (CDC) finds that vaccination provides better protection against hospitalization with COVID-19 than a previous infection with the virus.

    The analysis found people hospitalized with coronavirus-like symptoms were more than five times more likely to test positive for COVID-19 if they had had recent prior infection than if they were recently vaccinated.

    The study released Friday examined more than 7,000 people across nine states and 187 hospitals, comparing those who were unvaccinated and had previously had the coronavirus in the last three to six months and those who were vaccinated over the same time frame. "


    CBS: Vaccine offers more protection against COVID-19 than natural immunity, CDC study finds

    "Unvaccinated people who had survived a previous COVID-19 infection were more than five times more likely to be reinfected with the virus compared to those who were fully vaccinated with the Pfizer or Moderna vaccines, ..."


    CDC MMWR: Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021 | MMWR

    "What is added by this report?

    Among COVID-19–like illness hospitalizations among adults aged ≥18 years whose previous infection or vaccination occurred 90–179 days earlier, the adjusted odds of laboratory-confirmed COVID-19 among unvaccinated adults with previous SARS-CoV-2 infection were 5.49-fold higher than the odds among fully vaccinated recipients of an mRNA COVID-19 vaccine who had no previous documented infection (95% confidence interval = 2.75–10.99)."
     
  18. tochatihu

    tochatihu Senior Member

    Joined:
    Apr 10, 2004
    8,972
    3,501
    0
    Location:
    Kunming Yunnan China
    Vehicle:
    2001 Prius
    Can anyone provide data on current childhood (seasonal plain old) flu deaths vs. COVID-19 deaths? The latter's vaccine is now 'going younger'. CDC has for years advocated kid vax for flu.