Prius will start but won’t drive and Obd2 has issues communicating

Did you install a new actuator or a previously used one?
Have you installed all relays, safety switches etc that were removed for the job?

 

If you have brake and ABS lights, have you tried getting the blink codes? If so, what codes do you have?

Blink (a/k/a Flash) Codes – How to. | PriusChat

What reprgtamming have you done?

 

You’ve done a lot of work

I’d start trying to sort out the issues by getting Techstream - hacked version on eBay work well for me.

 

I think Gresham's law comes in a version for information on the internet. There is lousy information about what Tc/CG jumpering is for, which you can find endlessly repeated all over the ever-lovin' internet, and there is also a pretty good writeup for it, which you can find in one place, exactly here:

Blink (a/k/a Flash) Codes – How to. | PriusChat

As far as the trouble codes in the photo you posted, C1378 pertains to the capacitor power backup box in the rear of the car (next to the 12 volt battery), and C1253 and C1256 are familiar codes about the brake system's ability to pump up and retain working pressure. You can find troubleshooting information for all those in the repair manual:

Toyota Service Information and Where To Find It | PriusChat

That leaves the C1259 and C1310, which are reported by the brake system, but they are not brake system problems. These two codes are the brake system telling you that there are other codes being reported by the hybrid vehicle control ECU (the orchestra conductor for the car), and you need to go find those codes to understand what that's about. Those will be the codes that explain why the car won't drive.

When a scan tool shows C1259 and/or C1310 from the brake system, but doesn't show the underlying codes from the HV control ECU, that just means the scan tool isn't able to read those other codes, and a better scan tool has to be used. Regrettably, the HV control ECU doesn't understand the please-blink-your-codes trick.

 

Check the ABS code again; the blink codes are all two digits.

 

Did you do a complete brake fluid bleed through all parts of the brake actuator/accumulator using a scan tool to activate the brake bleed procedure? If not it may be in part why you cannot learn the linear offset, presuming you've tried to set the linear solenoid valve offset, that is. If you haven't you need to try to do that.

ABS
42: just means there are also codes on the ((!)) (ECB) light, go look at those.

Brake (ECB)
44 = C1244/44 | Open or Short in Acceleration Sensor Circuit

The yaw rate (deceleration) sensor detects any gravity applied to the vehicle and transmits the signal to the skid control ECU via CAN communication system (vehicle equipped with Enhanced VSC). The deceleration sensor is built into the yaw rate sensor and detects the vehicle condition in the 2 systems (GL1, GL2).

When a malfunction occurs in the communication line with the yaw rate sensor, DTC U0123/62 (yaw rate sensor communication malfunction) and DTC U0124/95 (deceleration sensor communication malfunction) are output.

DTCs C0371/71 and C1279/79 are deleted when the yaw rate and deceleration sensor sends a yaw rate and/or deceleration signal or test mode ends. DTCs C0371/71 and C1279/79 are output only in test mode.

66 = C1345/66 | Linear Solenoid Valve Offset Learning Undone

• The skid control ECU stores and corrects the difference in each individual part such as the stroke sensor, actuator solenoids, and stroke simulator solenoid. Perform "initialization of linear solenoid valve and calibration" if these parts are replaced. The skid control ECU inputs the shift position P signal.

 

The C1345 by itself is an easy one; the brake system just wants to learn its linear solenoid offset, and there's a simple procedure you go through so it can.

The C1244 might be a little more involved. I would want to look at the troubleshooting steps for that one in the repair manual:

Toyota Service Information and Where To Find It | PriusChat

 

I would venture to say you need to find a way – whether you beg, borrow, or beg again – to get hold of a better scan tool so you can do the brake bleed procedure. My feeling is your current problem could be in part because the ABS actuator has not been bled properly.

The best troubleshooting resource would be the Repair Manual. You might have luck finding a PDF copy for the 2006 MY by searching the Gen 2 forums (and their children) for "2006 Prius Repair Manual - 2006 PRIUS Electrical Wiring Diagram", which would contain differences to your 2005, but I don't think much changed with this area of the brakes. Of course, the gold standard would be to subscribe to TIS. More info here about those options, some free, some paid for.

If you want to find out more about scan tools that might be affordable you can read a review of them here.