SARS-CoV-2 Coronavirus (COVID-19)

Discussion in 'Environmental Discussion' started by tochatihu, Jan 26, 2020.

  1. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    95,270
    43,196
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
    well, i was on the patio until a few weeks ago :p
     
    Raytheeagle likes this.
  2. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    15,441
    8,703
    90
    Location:
    Western Washington
    Vehicle:
    2012 Prius
    Model:
    Three
    While decreasing, daily deaths are still well above the lows between earlier waves, and 4X above the rate of late June and early July:

    upload_2021-11-14_10-43-6.png

    We've been enjoying the outdoors all along. It was always safer than indoors.
     
  3. SFO

    SFO Senior Member

    Joined:
    Feb 7, 2017
    4,337
    3,907
    0
    Location:
    Northern California
    Vehicle:
    2007 Prius
    Model:
    N/A
  4. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    95,270
    43,196
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
    i remember reading about covid toes last year. mostly pediatric, they related it to kawasaki's disease iirc.
     
  5. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    95,270
    43,196
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
    has this already been posted? very interesting, although most of it is beyond me.
    s41586-021-03807-6
     
  6. SFO

    SFO Senior Member

    Joined:
    Feb 7, 2017
    4,337
    3,907
    0
    Location:
    Northern California
    Vehicle:
    2007 Prius
    Model:
    N/A
  7. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    24,778
    14,099
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
    • The researchers warn of a “cautionary tale” from efforts to create an HIV vaccine over a decade ago, where a promising vaccine candidate actually increased the risk of some men catching the virus.
    • The vaccine made use of a modified virus — called adenovirus 5 (Ad5) — as a vector to transport some of HIV’s genetic material into the body.
    • Exactly how the vaccine increased the risks of HIV transmission is unknown, but a conference convened by the National Institutes of Health recommended against further use of Ad5 as a vector in HIV vaccines (Dr. Anthony Fauci was lead author of the paper outlining this position.)
    The most effective is a protease inhibitor having NOTHING to do with the cited source.

    Bob Wilson
     
  8. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    15,441
    8,703
    90
    Location:
    Western Washington
    Vehicle:
    2012 Prius
    Model:
    Three
    This item is more than a year old. If the theoretical issue it brought up is being realized, there ought to be some followup by now.

    Dateline: Oct 20, 2020

    "Key Background


    Lots of vaccines make use of modified viruses to transport material into the human body. Many make use of a modified adenovirus to do this, a virus which is usually harmless except the ability to cause the common cold. Some of the leading candidates for a Covid-19 vaccine, including those from Johnson & Johnson and AstraZeneca, use adenoviruses as vectors. There is no evidence that those vectors increase the risk of HIV infection.

    Crucial Quote


    The authors said they went public because Ad5 vaccines for Covid-19 might soon be tested in populations with high HIV prevalence. Lawrence Corey, one of the authors who now co-leads the Covid-19 prevention network in the U.S. that is testing vaccines on behalf of the NIH, told Science that if he were in a sub-Saharan African country, where there’s a high prevalence of HIV, “I don’t see why I would pick an Ad5 vector (vaccine) when there are many other alternative choices.”
     
    Trollbait and bwilson4web like this.
  9. SFO

    SFO Senior Member

    Joined:
    Feb 7, 2017
    4,337
    3,907
    0
    Location:
    Northern California
    Vehicle:
    2007 Prius
    Model:
    N/A
  10. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    15,441
    8,703
    90
    Location:
    Western Washington
    Vehicle:
    2012 Prius
    Model:
    Three
    None of those are approved in the U.S.

    Two are approved in only a single E.U. country, a former member of the Soviet block.

    The third hasn't reached Phase III trials anywhere, let alone any approvals.

    As far as the U.S. vaxx controversies are concerned, that list has not yet risen above 'nothingburger' status
     
  11. tochatihu

    tochatihu Senior Member

    Joined:
    Apr 10, 2004
    8,281
    3,207
    0
    Location:
    Kunming Yunnan China
    Vehicle:
    2001 Prius
    Sputnik V vaccine is not (yet) on the WHO-approved list. This is relevant in US because only those vaccinated with WHO-approved get to enter. Full details at US Dept of State I suppose.
    It may get that EUA soon, so I have read.
    OTOH, 70 or so countries have themselves approved Sputnik V, more than any other vaccine's 'penetration'?
    ==
    Of all technologies now in use for COVID vaccines, I am least enthusiastic about adenovirus vectoring. Personal opinion only. Vaccine I received twice is Sinovac which is more or less 1950's tech.
    Viral replication for Sinovac is done in African green monkey kidney-cell culture, perhaps more tastefully called Vero cells. Just a good place for that to happen I guess.
    Virus gets separated so recipients don't get any Vero cells. Virus gets chemically denatured by beta propriolactone, a chemical you would not want in your body. What you get are virus 'shards' providing, according to trials, among the lowest efficacy of any approved vaccines.
    But there is is. Were a 3rd dose by an mRNA vaccine available, I'd snap that right up. But, not available on Taobao :D:D:D:)
    Sinovac also contains an adjuvant that has been used in anti-virals before. It has a funny name but the structure is trade secret. Adjuvants increase (your) immune responses to unrecognized molecules. I think they were first used in polio vaccines.
    (edit)
    Or, the adjuvant is alum, NH4Al(SO4)2.12 H2O Not really obvious from open lit. Alum is (or at least was) used to stop cuts from bleeding. Anyway, it's been around for a while.
     
    #5111 tochatihu, Nov 15, 2021
    Last edited: Nov 15, 2021
  12. tochatihu

    tochatihu Senior Member

    Joined:
    Apr 10, 2004
    8,281
    3,207
    0
    Location:
    Kunming Yunnan China
    Vehicle:
    2001 Prius
    African green monkeys as full-animal infection models have also been used in this viral research because they get sick and mount immune responses similar to humans. These are cute whole animals living in cages. Sort of an icky side of biomedical research, but I digress.

    To make Sinovac, cute is not included. countless cell-culture bottles shake on countless shaker tables. In a room somewhere I have no interest in entering.
     
  13. SFO

    SFO Senior Member

    Joined:
    Feb 7, 2017
    4,337
    3,907
    0
    Location:
    Northern California
    Vehicle:
    2007 Prius
    Model:
    N/A
    Always amazed at how many westerners think the world revolves around them, or their country.
     
  14. bwilson4web

    bwilson4web BMW i3 and Model 3

    Joined:
    Nov 25, 2005
    24,778
    14,099
    0
    Location:
    Huntsville AL
    Vehicle:
    2017 Prius Prime
    Model:
    Prime Plus
    Good thing it is only ‘Westerners’. The rest of the Earth’s population is so magnanimous.

    Bob Wilson
     
  15. fuzzy1

    fuzzy1 Senior Member

    Joined:
    Feb 26, 2009
    15,441
    8,703
    90
    Location:
    Western Washington
    Vehicle:
    2012 Prius
    Model:
    Three
    Always amazed at how many folks bring non-U.S. factors into a primarily U.S.-centric flood of scaremongering.

    To repeat:
     
    #5115 fuzzy1, Nov 16, 2021
    Last edited: Nov 16, 2021
    privilege likes this.
  16. privilege

    privilege Active Member

    Joined:
    Mar 17, 2021
    563
    146
    0
    Location:
    Birmingham
    Vehicle:
    2011 Prius
    Model:
    Three
    bless your heart
     
  17. privilege

    privilege Active Member

    Joined:
    Mar 17, 2021
    563
    146
    0
    Location:
    Birmingham
    Vehicle:
    2011 Prius
    Model:
    Three

    lol that was pretty good ! :-D
     
  18. bisco

    bisco cookie crumbler

    Joined:
    May 11, 2005
    95,270
    43,196
    0
    Location:
    boston
    Vehicle:
    2012 Prius Plug-in
    Model:
    Plug-in Base
  19. SFO

    SFO Senior Member

    Joined:
    Feb 7, 2017
    4,337
    3,907
    0
    Location:
    Northern California
    Vehicle:
    2007 Prius
    Model:
    N/A


    Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection - Physical Chemistry Chemical Physics (RSC Publishing)



    The identification of chemical compounds able to bind specific sites of the human/viral proteins involved in the SARS-CoV-2 infection cycle is a prerequisite to design effective antiviral drugs. Here we conduct a molecular dynamics study with the aim to assess the interactions of ivermectin, an antiparasitic drug with broad-spectrum antiviral activity, with the human Angiotensin-Converting Enzyme 2 (ACE2), the viral 3CLpro and PLpro proteases, and the viral SARS Unique Domain (SUD). The drug/target interactions have been characterized in silico by describing the nature of the non-covalent interactions found and by measuring the extent of their time duration along the MD simulation. Results reveal that the ACE2 protein and the ACE2/RBD aggregates form the most persistent interactions with ivermectin, while the binding with the remaining viral proteins is more limited and unspecific.

    [​IMG]
     
Loading...
Similar Threads - SARS Coronavirus COVID
  1. bwilson4web
    Replies:
    38
    Views:
    2,090
  2. hill
    Replies:
    0
    Views:
    1,566