I've been running around the forums and my reference manuals trying to nail this one. P0300 p0301 p0303 were set. 2006 prius btw... I drove it around with my scan tool (snap on modis) watching the misfire histograms. I replaced the spark plugs and dried out the spark plug wells of any moisture because I had 'just' washed the car before the misfire happened. Much to my dismay, the misfire was still present and constant. I had a dead number 3 cylinder. I swapped coils with another and number 3 was still racking up misfires. So it wasn't a coil issue. I pulled out the #3 plug and put in a new one in case the replacement was a dud. No good. Still misfiring. I pulled out the number 3 ignition coil and inserted a known good plug. It was lighting off like a Chinese New Year, so it's definitely being commanded to fire. I poke n prod trying to find a wet connector, something loose, who knows what. Nothing jumps out at me. I performed an injector disable test. 1,2, and 4 drop rpm's but 3 does nothing. It's been a LONG time since I've found a bad injector but I think tonight is a first. Call me wacky, but when cylinders 1,2, and 4 have a resistance of ~12.5 ohms with a bastard number 3 injector reading 14.5 KILO-ohms... makes ya wonder. I haven't found another thread on Priuschat of anyone coming to the same conclusion. If someone has, I'd like to read their story. At this point in time, I'm sourcing a replacement fuel injector.